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NINDS Disorders is an index of neurological conditions provided by the National Institute of Neurological Disorders and Stroke. This valuable tool offers detailed descriptions, facts on treatment and prognosis, and patient organization contact information for over 500 identified neurological disorders.

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Striatonigral Degeneration

Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.

Treatment

There is no cure for striatonigral degeneration, and treatments for the disorder have variable success. Treatments used for Parkinson's disease are recommended. However, unlike Parkinson's disease, striatonigral degeneration is not responsive to levodopa. Dopamine and anticholinergics provide some benefit. Generally, treatment is reevaluated as the disorder progresses.

Prognosis

Striatonigral degeneration progresses slowly. Some patients have normal life expectancy.

Research

The NINDS supports and conducts research on disorders of the brain and nervous system such as striatonigral degeneration. This research focuses on finding ways to prevent and treat these disorders.

View a list of studies currently seeking patients.

View more studies on this condition.

Organizations

National Organization for Rare Disorders (NORD)

Federation of voluntary health organizations dedicated to helping people with rare "orphan" diseases and assisting the organizations that serve them. Committed to the identification, treatment, and cure of rare disorders through programs of education, advocacy, research, and service.

55 Kenosia Avenue
Danbury, CT 06810
Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)
Fax: 203-798-2291

American Parkinson Disease Association

Seeks to “Ease the Burden – Find the Cure” through funding scientific research. Provides comprehensive patient/caregiver support and education.

135 Parkinson Avenue
Staten Island, NY 10305-1425
Tel: 718-981-8001 800-223-2732 Young Onset Center: 877-223-3801
Fax: 718-981-4399

National Parkinson Foundation

Provides research, patient services, clinical studies, public and professional education, and physician referrals at over 60 locations and through a nationwide network of chapters and support groups.

200 SE 1st Street
Suite 800
Miami, FL 33131
Tel: 305-243-6666 Helpline 800-473-4636
Fax: 305-243-5595

Parkinson's Action Network (PAN)

Non-profit education and advocacy organization that serves as a voice for the Parkinson's community by fighting for promising research that will produce effective treatments and a cure.

1025 Vermont Ave., NW
Suite 1120
Washington, DC 20005
Tel: 800-850-4726 202-638-4101
Fax: 202-638-7257

Parkinson's Disease Foundation (PDF)

National nonprofit organization that supports Parkinson's disease research, education, and public advocacy programs.

1359 Broadway
Suite 1509
New York, NY 10018
Tel: 212-923-4700 800-457-6676
Fax: 212-923-4778

The Multiple System Atrophy Coalition

National support group that collects and disseminates information and promotes education and support for people affected by Shy-Drager Syndrome or multiple system atrophy.

8311 Brier Creek Parkway
Suite 105-434
Raleigh, NC 27617
Tel: 1-866-737-5999

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