E-Pearl of the Week

June 28, 2011


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June 27, 2011

Melkersson-Rosenthal Syndrome

Melkersson-Rosenthal Syndrome is an uncommon cause of facial nerve palsy. It is a granulomatous neurocutaneous disease of unclear etiology with a possible familial component. The peripheral facial nerve palsy may be unilateral or bilateral. The characteristic clinical triad consists of facial nerve palsies, a plicated – or fissured - tongue, and orofacial edema. The diagnosis can be difficult because only 8-18% of patients present with the entire triad.


  1. Ozgursoy OB, Ozgursoy SK, Tulunay O, et al. Melkersson Rosenthal Sydrome revisited as a Misdiagnosed Disease. American Journal of Otolaryngology 2009; 30: 33-37.

Submitted by:
Alendia Hartshorn, MD

Disclosure: Dr. Hartshorn reports no disclosures.

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