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May 17, 2011
Lafora bodies are a pathologic hallmark of progressive myoclonic epilepsy, or Lafora disease. These inclusion bodies are accumulations of abnormal glycogen (polyglucosans) which are insoluble and precipitate in neuronal cytoplasm. This abnormal glycogen is also produced inside astrocytes but doesn't accumulate because astrocytes have glycogen phosphorylase and it is quickly degraded. Thus, Lafora bodies are seen in neurons and not in astrocytes. Lafora bodies can also be found in other glycogen storage cells such as heart, sweat glands, liver and muscles.
Aamir Hussain, MD
Disclosure: Dr. Hussain has nothing to disclose.
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