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October 31, 2012
Functional Neuroimaging in Kleine–Levin syndrome
Kleine–Levin syndrome predominantly affects adolescent males and is clinically defined by repeated episodes of hypersomnia and cognitive and behavioral abnormalities such as hyperphagia and hypersexuality. These episodes usually last days to weeks, and patients have normal behavior and sleep in the intervening weeks or months. Functional neuroimaging has been performed in individual cases or small series of patients during symptomatic episodes. The most consistent finding in studies using SPECT is thalamic hypoperfusion. FDG–PET scans have shown increased brain glucose metabolism in the anterior caudate nuclei, cingulate gyri, and premotor cortex and decreased metabolism in the hypothalamus, orbitofrontal and frontal parasagittal areas, and posterior regions.
Submitted by: Jennifer E. Fugate, DO
Disclosure: Dr. Fugate serves on the editorial team for the Neurology Resident and Fellow Section.
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