E-Pearl of the Week: Panayiotopoulos Syndrome

August 1, 2012


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August 1, 2012

Panayiotopoulos Syndrome

Panayiotopoulos syndrome is a common, but underdiagnosed, benign childhood epilepsy syndrome. The syndrome is characterized by autonomic seizures occurring in developmentally normal children. The most common feature is vomiting. Changes in pupil size, cardiorespiratory status and thermoregulation, pallor, eye deviation, convulsions, and syncopal-like symptoms can also occur. Seizures can be prolonged but are infrequent; one quarter of children experience just one episode. The interictal EEG is highly variable, but frequently reveals occipital spikes. Remission occurs within 3 years of onset, often without prophylactic antiepileptic medication.


1. Ferrie C, Caraballo R et al. Panayiotopoulos syndrome: a consensus view. Developmental Medicine & Child Neurology 2006; 48: 236–240.

Submitted by: Nadine McCrea, Pediatric Neurology Registrar, Cambridge, UK.

Disclosures: Dr. McCrea reports no disclosures.

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