E-Pearl of the Week: Frontotemporal Dementia

June 6, 2012


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Brought to you by the Resident and Fellow Section of Neurology®.

June 5, 2012

Frontotemporal Dementia

Frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration or FTLD, is a term used to describe a diverse group of dementias that primarily affect the frontal and temporal lobes of the brain.  Symptoms can include behavioral changes, speech and language problems, and movement disorders.  FTD tends to occur at a younger age than Alzheimer's disease, with onset typically between age 40 and 70.  About 40% of people with FTD have tau–positive inclusions, historically known as Pick bodies, while other patients have inclusions composed of ubiquitin and TDP–43.  Read about the presence of abnormal saccadic eye movements in FTD in this week’s issue of Neurology. 


1.  Burrell JR, Hornberger M, Carpenter RHS, et al. Saccadic abnormalities in frontotemporal dementia. Neurology 2012; 78:1816–1823.
2. Gorno–Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology 2011; 76:1006–1014.
3.  Liscic RM, Storandt M, Cairns NJ, et al. Clinical and Psychometric Distinction of Frontotemporal and Alzheimer Dementias.  Archives of Neurology 2007; 64(4).

Submitted by: Stacey L. Clardy, MD, PhD

Disclosure: Dr. Clardy serves on the editorial team for the Neurology® Resident and Fellow Section.

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