E-Pearl of the Week: Möbius Syndrome

January 9, 2012


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January 9, 2011

Möbius Syndrome

Möbius syndrome is a rare congenital disorder characterized by facial and abducens nerve palsy. Children are unable to smile, frown, grimace, suck, blink, or move their eyes laterally. Examination reveals convergent strabismus, facial diplegia, retrognathism, palatine and dental malformations. Most have normal intelligence. Möbius syndrome is sometimes associated with limb, orofacial, or chest wall abnormalities. The pathogenesis is unclear, but is thought to be vascular or genetic. 


1. von Graefe A. Handbuch der Gesammten Augenheilkunde. In:  von Graefe A, Saemisch T editor. Leipzig: Engelmann; 1880; p.60.
2. Moebius PJ. Ueber angeborene doppelseitige Abducens–Facialis–Laehmung. Munch Med Wschr 1888; 35:91—94.

Submitted by: Vijayamala Bondugula, MD

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