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NINDS Disorders is an index of neurological conditions provided by the National Institute of Neurological Disorders and Stroke. This valuable tool offers detailed descriptions, facts on treatment and prognosis, and patient organization contact information for over 500 identified neurological disorders.

Neurology Now
Letter: Speak Up: Alzheimer's disease 11.01.2012
Searching for the Early Signs of Alzheimer's Disease 11.01.2012
Speak Up: The Mother I Knew 09.01.2012
In the Pipeline: Skin-cancer drug tested in mice with model of Alzheimer's disease 07.01.2012
Speaking of Alzheimer's: CBS Broadcaster Jim Nantz's famous voice has never been clearer 02.01.2012
Neurobics: Dot Matrix, a brain teaser that tests your number and spatial thinking. 10.01.2011
A Pocket Guide for the Alzheimer's Caregiver 10.01.2011
Neurobics: Look Closely, a brain teaser that tests your visual skills. 08.01.2011
Neurobics: Name Recognition 06.01.2011
Some Kind of Wonderful, Indeed: For actress Lea Thompson, Alzheimer's disease advocate is the role of a lifetime 04.01.2011
Clinical Trial Watch: Family Mission—By joining studies, the Noonans are helping unravel the mystery of Alzheimer's disease 04.01.2011
Alzheimer's Disease Studies 04.01.2011
Neurobics: Cubical Condos 11.01.2010
Come Together: Actors Jill Eikenberry and Michael Tucker on how Alzheimer's disease has made their family bond stronger. 11.01.2010
Support for Alzheimer's Patients and Their Families 11.01.2010
NEUROBICS: Lost in Migration 09.01.2010
Neurobics: Flexible Thinking 07.01.2010
Mind Games: Computerized cognitive exercise is big business. But do the industry's claims stand up? 07.01.2010
New Imaging Captures the Brain's Complexity 05.01.2010
Color Confusion 05.01.2010
When Should People With Dementia Stop Driving? 05.01.2010
Cindy's Campaign 05.01.2010
Wandering With Alzheimer's. 01.01.2010
MEMORY SCREENING: November 17: National Memory Screening Day. 11.01.2009
Terra Incognita. 11.01.2009
The "Other" Dementias. 11.01.2009
Alzheimer's Disease. 09.01.2009
Alzheimer's Disease. 09.01.2009
Your Heart, Your Belly and Alzheimer's: People with so-called "metabolic syndrome" may be at a higher risk of developing Alzheimer's disease and dementia. Here's what you should know.. 07.01.2009
Who's There?: When stroke or Alzheimer's changes a person's behavior, caregiving can become extreme. Here, experienced caregivers, patients, and experts share their stories and advice.. 07.01.2009
SCREENING ROOM: HBO Documents Life with Alzheimer's Disease. 05.01.2009
Thinking about Ginkgo?. 03.01.2009
Pictures of You. 03.01.2009
Discovering Art. 03.01.2009
Diminished Capacity. 11.01.2008
Maximize Your Drug Plan. 11.01.2008
Hidden Pressure. 09.01.2008
Neuro Blogs. 07.01.2008
Driving advice for people with epilepsy, Parkinson's, and Alzheimer's, and their families.. 07.01.2008
Transportation Options. 07.01.2008
The Alzheimer's Pipelinescientists: Scientists are optimistic about the slew of new treatments being tested. 05.01.2008
Brain Food. 03.01.2008
Your Questions Answered: LEWY BODY DEMENTIA. 11.01.2007
Your Questions Answered: STATINS AND MEMORY. 09.01.2007
What the Nose Knows. 09.01.2007
Calling Caregivers of Color. 07.01.2007
Patched Up. 07.01.2007
Reaching Out: The importance of human connection in the face of chronic illness.. 05.01.2007
Raise the Curtain: David Hyde Pierce shines a light on Alzheimer's disease.. 05.01.2007
Swimming for Alzheimer's. 03.01.2007
Life After Alzheimer's: How patients continue to laugh, love, and give back to their community. 01.01.2007
Diagnosing and treating early,Stage alzheimer's. 01.01.2007
SAVING SERGEANT RADKE. 09.01.2006
SAVING BRAIN CELLS?: Researchers seek treatments to minimize the damage. 09.01.2006
Dementia Drugs Demystified: What to expect-and not to expect-from Alzheimer's medications. 09.01.2006
Your Questions Answered: ALZHEIMER'S. 07.01.2006
NEWS SCAN The Road to Wellness via Diet and Exercise. 01.01.2006
My Father's Brain. 01.01.2006
AAN Patient Guidelines
AAN Press Releases
Study: Link Between Vitamin D and Dementia Risk Confirmed 08.06.2014
Two Researchers Receive $130,000 Each for Research into Neurotoxin Treatment for Alzheimer’s, Dystonia 04.30.2014
Study: Alzheimer’s Disease a Much Larger Cause of Death Than Reported 03.05.2014
Two Parents with Alzheimer’s Disease? Disease May Show up Decades Early on Brain Scans 02.12.2014
Can Fish Oil Help Preserve Brain Cells? 01.22.2014
Are Concussions Related to Alzheimer’s Disease? 12.26.2013
High Blood Pressure in Middle Age Versus Old Age May Better Predict Memory Loss 11.13.2013
Lower Blood Sugars May Be Good for the Brain 10.23.2013
In Elderly, Hardening of Arteries Linked to Plaques in Brain 10.16.2013
Anemia Linked to Increased Risk of Dementia 07.31.2013
People with Alzheimer’s Disease May Have Lower Risk of Cancer and Vice Versa 07.10.2013
Skin Cancer May Be Linked to Lower Risk of Alzheimer’s Disease 05.15.2013
New Add-On Drug May Improve Memory in People with Moderate Alzheimer’s Disease 03.11.2013
Researchers Identify Possible Treatment Window for Memory Problems 02.27.2013
Study: Number of People with Alzheimer’s Disease May Triple by 2050 02.06.2013
$100,000 Potamkin Prize for Alzheimer’s Research Awarded to Three Neurologists 01.24.2013
New MRI Method May Help Diagnose Dementia 12.26.2012
People Without Spouses Under-represented in Alzheimer’s Clinical Trials 12.19.2012
Can Going Hungry As a Child Slow Down Cognitive Decline in Later Years? 12.10.2012
Timing is Everything: Hormone Use May Reduce or Increase Alzheimer’s Disease Risk in Women 10.24.2012
Plaque Build-up in Your Brain May Be More Harmful than Having Alzheimer’s Gene 10.15.2012
Obesity, Metabolic Factors Linked to Faster Cognitive Decline 08.20.2012
Resistance to Dementia May Run in the Family 08.15.2012
New Biomarker in the Blood May Help Predict Alzheimer’s Disease 07.18.2012
Eating Fish, Chicken, Nuts May Lower Risk of Alzheimer’s Disease 05.02.2012
Washington University Researcher Awarded $130,000 Alzheimer’s Research Grant 04.25.2012
Get Moving: Daily Exercise May Reduce Alzheimer’s Disease Risk at Any Age 04.18.2012
New Method May Help Detect Marker for Alzheimer’s Disease Earlier 04.15.2012
Studies: Memory Declines Faster In Years Closest to Death; Mental Activity Best Protection 04.04.2012
Low Levels of Omega-3 Fatty Acids May Cause Memory Problems 02.27.2012
Tokyo Neurologist Wins $100,000 Potamkin Prize for Alzheimer’s Research 02.21.2012
Overeating May Double Risk of Memory Loss 02.12.2012
Marker for Alzheimer’s Disease May Affect Mental Function Even in Healthy Adults 02.01.2012
Clinical Trial: Nicotine Patch Shows Benefits in Mild Cognitive Impairment 01.09.2012
Diet Patterns May Keep Brain from Shrinking 12.28.2011
New Clues as to Why Some Older People May Be Losing Their Memory 12.28.2011
Brain Size May Predict Risk for Early Alzheimer’s Disease 12.21.2011
Is It Alzheimer’s Disease or Another Dementia? Marker May Give More Accurate Diagnosis 11.30.2011
People with Early Alzheimer’s Disease May Be More Likely to Have Lower BMI 11.21.2011
PSA on Finding Cure for Brain Disease Marks 20th Anniversary of AAN Foundation 10.11.2011
Low Vitamin B12 Levels May Lead to Brain Shrinkage, Cognitive Problems 09.26.2011
Diabetes May Significantly Increase Your Risk of Dementia 09.19.2011
Study Reveals Link Between High Cholesterol and Alzheimer’s Disease 09.12.2011
Study Identifies Chemical Changes in Brains of People at Risk for Alzheimer's Disease 08.24.2011
Study: Alzheimer’s Disease Symptoms More Subtle in People Over 80 08.10.2011
Keeping up Your Overall Health May Keep Dementia Away 07.13.2011
New Biomarker May Help with Early Diagnosis of Alzheimer’s Disease 06.22.2011
Study: Memory Problems Often Not Present in Middle-Aged People with Alzheimer’s Disease 05.16.2011
Packing on the Pounds in Middle Age Linked to Dementia 05.02.2011
Actress Lea Thompson Hosts New, Free Video to Help People with Alzheimer’s Disease 04.13.2011
Brain Starts Shrinking Nearly a Decade Before Alzheimer’s Appears 04.13.2011
Treating High Blood Pressure, Cholesterol, Diabetes May Lower Risk of Alzheimer’s Disease 04.13.2011
Winners of Neuro Film Festival Announced 04.11.2011
Actress Lea Thompson Hosts New, Free Video to Help People with Alzheimer’s Disease 04.06.2011
More Evidence That Alzheimer’s Disease May Be Inherited from Your Mother 02.28.2011
Alzheimer’s Disease May Be Easily Misdiagnosed 02.23.2011
Three Researchers Awarded $100,000 Potamkin Prize from AAN 02.17.2011
Netherlands Researcher Receives AAN’s Sheila Essey Award for ALS Research 02.16.2011
Last Call for Entries: Public Asked to Submit Videos to 2011 Neuro Film Festival 01.11.2011
Holiday Recipe Help for People with Trouble Smelling and Tasting Food 12.16.2010
Mid-life Cholesterol Levels Not Linked to Alzheimer’s Disease 11.10.2010
Vitamin B12 May Reduce Risk of Alzheimer’s Disease 10.18.2010
Walk Much? It May Protect Your Memory Down the Road 10.13.2010
Study: Old Age May Not Be to Blame for Becoming Forgetful 09.15.2010
Memory Problems More Common in Men? 09.06.2010
Brain Exercises May Slow Cognitive Decline Initially, But Speed Up Dementia Later 09.01.2010
Insulin Resistance, Type 2 Diabetes Linked to Plaques Associated with Alzheimer’s Disease 08.25.2010
Larger Head Size May Protect Against Alzheimer’s Symptoms 07.12.2010
Depression May Nearly Double Risk of Dementia 07.05.2010
New Study Identifies Best Tests for Predicting Alzheimer’s Disease 06.30.2010
New Gene Associated with Increased Risk of Alzheimer’s Disease 04.14.2010
AAN Foundation Awards $130,000 Fellowship in Alzheimer’s Research to UCSF Researcher 04.13.2010
AAN Issues Guideline on When People with Alzheimer’s Disease Should Stop Driving 04.12.2010
Protein Linked to Problems with Executive Thinking Skills 03.29.2010
Memory May Decline Rapidly Even in Stage Before Alzheimer’s Disease 03.22.2010
Two Researchers Awarded $100,000 Potamkin Prize from AAN 02.18.2010
Vote Now for Your Favorite 2010 Neuro Film Festival Video 02.17.2010
Two Researchers Awarded $100,000 Potamkin Prize from AAN 02.11.2010
Mediterranean Diet May Lower Risk of Brain Damage That Causes Thinking Problems 02.08.2010
Memory Failing? You May Be at Higher Risk for Stroke 02.01.2010
Drowsiness, Staring, and Other Mental Lapses May Signal Alzheimer’s Disease 01.18.2010
Study: New Brain Scan Better Detects Earliest Signs of Alzheimer’s Disease in Healthy People 01.06.2010
Alzheimer’s Disease May Protect Against Cancer and Vice Versa 12.23.2009
Does Diabetes Speed Up Memory Loss in Alzheimer’s Disease? 10.26.2009
Problems Managing Money May Surface Shortly Before Alzheimer’s Disease Sets In 09.21.2009
Infections May Lead to Faster Memory Loss in Alzheimer’s Disease 09.07.2009
High Blood Pressure Linked to Memory Problems in Middle Age 08.24.2009
Immunotherapy Linked to Lower Risk of Alzheimer’s Disease 07.20.2009
Depression May Increase Risk of Alzheimer’s Disease in People with Memory Problems 06.15.2009
Staying Sharp: New Study Uncovers How People Maintain Cognitive Function in Old Age 06.08.2009
Weight Loss in Old Age May Signal Dementia 05.18.2009
New Tool Can Help Predict Risk of Alzheimer’s in Elderly 05.13.2009
Delirium May Cause Rapid Cognitive Decline in Alzheimer’s Disease 05.04.2009
Shrinking in Hippocampus Area of Brain Precedes Alzheimer’s Disease 03.16.2009
Tests May Predict Driving Safety in People with Alzheimer’s Disease 02.09.2009
Does Growth Hormone Drug Slow Alzheimer’s Disease? 11.17.2008
Diabetes, High Blood Pressure May Cause People with Alzheimer’s Disease to Die Sooner 11.03.2008
Education Protects Against Pre-Alzheimer’s Memory Loss 10.20.2008
Physical Frailty May be Linked to Alzheimer’s Disease 08.11.2008
Exercise May Prevent Brain Shrinkage in Early Alzheimer’s Disease 07.14.2008
Ibuprofen, Aspirin, Naproxen May be Equally Effective at Reducing Risk of Alzheimer’s Disease 05.28.2008
Ibuprofen Linked to Reduced Risk of Alzheimer’s Disease 05.05.2008
High Cholesterol in Your 40s Increases Risk of Alzheimer's Disease 04.16.2008
Alzheimer’s Starts Earlier for Heavy Drinkers, Smokers 04.16.2008
Vitamin E May Help Alzheimer’s Patients Live Longer 04.15.2008
Diabetes in Mid-Life Linked to Increased Risk of Alzheimer’s Disease 04.09.2008
Depression Increases Risk of Alzheimer’s Disease 04.07.2008
Three Researchers Awarded AAN Potamkin Prize for Alzheimer’s Research 04.07.2008
Cholesterol-Lowering Drugs May Not Prevent Alzheimer’s Disease 01.16.2008
Latinos and African Americans Live Longer with Alzheimer’s Disease 11.14.2007
High Blood Pressure, Chest Pains Speed Up Progression of Alzheimer’s Disease 11.05.2007
Mediterranean Diet May Help Alzheimer’s Patients Live Longer 09.10.2007
Drug Improves Symptoms of Severe Alzheimer’s Disease 07.30.2007
Frequent Brain Stimulation in Old Age Reduces Risk of Alzheimer’s Disease 06.27.2007
Strengthening Exercises May Slow Progression of ALS 06.04.2007
Blood Inflammation Plays Role in Alzheimer’s Disease 05.28.2007
Brain Scans Show Early Alzheimer’s Disease in People with Memory Problems 05.07.2007
Estrogen Use Before 65 Linked to Reduced Risk of Alzheimer’s Disease 05.02.2007
Commonly Used Pain Medications Do Not Prevent Alzheimer’s Disease 04.25.2007
Columbia University Neurologist Awarded AAN’s Potamkin Prize for Alzheimer’s Research 04.11.2007
Counseling for Spouses Keeps Alzheimer’s Patients out of Nursing Homes 11.13.2006
Alzheimer’s Pathology Related to Episodic Memory in Those without Dementia 06.26.2006
Junior Soprano Gets Tough on Alzheimer’s 06.01.2006
Midlife Obesity Raises Risk of Alzheimer’s Disease Later 03.24.2006
American Academy of Neurology Awards 2006 Potamkin Prize to Three Neuroscientists for Research in Alzheimer’s Disease 03.23.2006
Is It Okay to Sign Alzheimer’s Patients Up for Research Studies? 11.07.2005
Study Evaluates Alzheimer’s Patients’ Ability to Make Decisions about Treatment 05.09.2005
Spirituality, Religious Practice May Slow Progression of Alzheimer’s Disease 04.13.2005
Public Leadership in Neurology Award Honors Leeza Gibbons for Alzheimer’s Awareness Efforts 04.13.2005
2005 Potamkin Prize Awarded to Two Neurologists for Research in Early, Preclinical Detection of Alzheimer’s Disease 04.05.2005
Blood Pressure Drugs May Slow Deterioration of Alzheimer’s 10.11.2004
Mild Alzheimer’s Leads to Errors on Driving Test 09.13.2004
Mentally Demanding Jobs May Protect Against Alzheimer’s Disease 08.09.2004
American Academy of Neurology Awards 2004 Potamkin Prize to Two Scientists Instrumental in Developing Alzheimer’s Disease Therapies 04.21.2004
Genes Influence Memory in Families with Alzheimer’s Disease 02.09.2004
Distress-Prone People More Likely to Develop Alzheimer’s Disease 12.08.2003
Genetic Abnormalities Found in Some ALS Patients 04.21.2003
DHEA Supplement Shows No Effect on Alzheimer’s Disease 04.07.2003
NSAIDS May Offer Protection Against Alzheimer’s Disease 03.31.2003
2003 Potamkin Prize Honors Shared by Two Alzheimer’s Disease Researchers 03.07.2003
Medical Groups Agree: Resources for Treating People with Alzheimer's Are Available but Underutilized 12.05.2002
Can Alzheimer’s Disease Be Slowed By Shunting Cerebrospinal Fluid? 10.21.2002
Growing Evidence that Commonly Used Medicines May Delay or Prevent Alzheimer’s Disease 09.23.2002
Study Points to Depression as a Risk for Developing Alzheimer's Disease 08.12.2002
Alzheimer's Drug Improves Pilots' Performance on Tests 07.08.2002
Statin Drugs May Lower Risk of Alzheimer's 04.16.2002
2002 Potamkin Prize Recognizes the Ground-Breaking Work of Alzheimer's Disease Researchers in Germany, Belgium 04.11.2002
Alzheimer's Disease with Psychotic Behaviors Aggregates in Families 03.25.2002
Leisure Activity Decreases Risk of Alzheimer's Disease 12.24.2001
Small Head Circumference Coupled with ApoE e4 Gene is a Factor in Alzheimer's Disease 10.22.2001
Estrogen Patch May Improve Memory for Women with Alzheimer's 08.27.2001
Alzheimer's Patients Taking Drug Maintain Daily Activities Longer 08.13.2001
Study Links APOE?4 and Alzheimer’s Disease in Very Elderly 06.25.2001
Research Ties Vitamin B12 and Folate Deficiencies with Alzheimer's Disease 05.07.2001
Neurology Today
Antibody Reduced Plaque By More Than Half in Animal Model of Alzheimer's Disease 01.17.2013
New Genetic Variant Implicated in Alzheimer's Disease 12.20.2012
NEWS FROM THE SOCIETY FOR NEUROSCIENCE ANNUAL MEETING: MRI Probe for Amyloid-Beta Oligomers Offers Potential Advantages for Detecting Alzheimer's Disease 12.20.2012
How do Hormonal Changes in Women Affect Alzheimer's Disease? 12.06.2012
Alzheimer's Disease Patients Taken Off Risperidone Are More Likely to Relapse, New Study Finds 12.06.2012
AD Prevention Trial Moves Forward: The Opportunities and the Risks 11.15.2012
NEWS FROM THE AMERICAN NEUROLOGICAL ASSOCIATION ANNUAL MEETING: Anti-Amyloid-Beta Drug Modestly Slows Cognitive Decline in Mild to Moderate AD 11.01.2012
NEWS FROM THE AMERICAN NEUROLOGICAL ASSOCIATION ANNUAL MEETING: Alzheimer's Disease May Progress at Slower Rate Than Believed 11.01.2012
Disrupted Sleep-wake Cycle Associated with Abeta Aggregation, Suggesting a Potential Biomarker for Alzheimer's Disease 10.04.2012
NEWS FROM THE ALZHEIMER'S ASSOCIATION INTERNATIONAL CONFERENCE: Old Drug, New Treatment for Apathy in Alzheimer's Disease 10.04.2012
NEWS FROM THE ALZHEIMER'S ASSOCIATION INTERNATIONAL CONFERENCE: Risky Business: How to Disclose Risk for Alzheimer's Disease Responsibly 10.04.2012
News from the Alzheimer's Association International Conference: In Late Life, Low Blood Pressure Reportedly Increases Dementia Risk 09.20.2012
Bapineuzumab for Alzheimer's: Don't Write Off Negative Results Just Yet, Experts Say 09.06.2012
Rare Mutation Associated with Inhibiting Alzheimer's Disease 09.06.2012
Biomarkers for Inherited Alzheimer's Disease Emerge Decades Before Symptoms Manifest 08.16.2012
Biomarkers for Inherited Alzheimer's Disease Emerge Decades Before Symptoms Manifest 08.16.2012
White Matter Injury Found to Be Preclinical Marker for Age-related Cognitive Decline: 08.16.2012
Amyloid Beta Aggregates in Alzheimer's Disease Are Prions, Study Finds 07.19.2012
ASK THE NEUROETHICIST: A Common Conundrum — and Against All Odds: “I Want You to Do Everything to Save Her!” 07.19.2012
Plans Under Way for Alzheimer's Prevention Trial 06.21.2012
Investigators Identify Cytokine Target for APOE-Mediated Neurovascular Injury 06.21.2012
News from the AAN Annual Meeting: Two Radioactive Tracers Detect Amyloid, May Aid in AD Diagnosis 05.17.2012
‘Village of the Demented’ Draws Praise as New Care Model 05.17.2012
FDA Approves Florbetapir for Imaging Amyloid Beta for Alzheimer Disease 05.17.2012
Two Drugs Are Not Better Than One for Treating Moderate to Severe Alzheimer Disease, British Investigators Report: Why Some US Neurologists Don't Agree 04.19.2012
Two Labs, Same Conclusion: Alzheimer Disease Spreads from Neuron to Neuron 03.15.2012
Will the Revised MCI Criteria Mean Fewer Alzheimer Disease Diagnoses? 03.15.2012
Cancer Drug Clears Amyloid Beta, Improves Behavior in Alzheimer Disease Mice 03.01.2012
Feds Promote Alzheimer Disease Initiative — Experts Ask: Where is the Money? 02.16.2012
Another Piece in the Alzheimer Disease Puzzle: The Role of Cortical Atrophy 02.16.2012
What A New Research Model Reveals About Alzheimer Pathology. 02.02.2012
New Data on the Role of Hypoxia in Alzheimer Disease. 02.02.2012
Gene Transfer of Growth Factor Improves Alzheimer Symptoms in Mice 01.19.2012
Growing List of Positive Effects of Nicotine Seen in Neurodegenerative Disorders 01.19.2012
At Unique ALS Meeting, New Discoveries, Paradigms, and Complexities Are Front and Center 11.03.2011
Alzheimer Cascade Starts Two Decades Before Symptoms 10.20.2011
New Alzheimer Disease Advisory Panel to Shape Federal Agenda on Disease 09.15.2011
Up & Coming: Jee Hoon Roh, MD, PhD: Exploring the Sleep-Wake Cycle as a Target for AD Intervention 09.01.2011
When to Test for AD Genetics: New Guidelines Offer Guidance 08.18.2011
News from the AAN Annual Meeting: Multiple Pathologies in Many Alzheimer Disease Patients 06.02.2011
New Data: Posterior Cortical Atrophy Shares Similarities with Alzheimer Disease 05.05.2011
Up to Ten-Year Decline Before Alzheimer Disease, According to Longitudinal Study 05.05.2011
Clusterin Levels in the Blood Indicate Severity of Alzheimer Disease But Are Not a Predictor 05.05.2011
Cell Phones Can Change Brain Metabolism — But What Does That Mean for Disease? 03.17.2011
FDA Panel Recommends New Imaging Agent for AD Detection 02.17.2011
Letters to the Editor: The Right Funding Numbers for AD Research 02.03.2011
Legislation Creates National Agenda on Alzheimer Disease, Though No New Funds 01.20.2011
AD Vaccine Targeting Tau Promising in Early Animal Studies 01.06.2011
Federal Funding Challenges Affect Alzheimer Disease Research as Stimulus Funds Wane 12.16.2010
AD Patients Not Helped By Fish Oil Ingredient, Study Reports 11.18.2010
Biomarker Identified for Accelerated Aging in Down Syndrome 11.04.2010
Diabetes-Associated Gene is Found to Regulate Alzheimer Disease Amyloid Metabolism 11.04.2010
Combined Biomarkers May Help Distinguish Between Alzheimer Disease and Lewy Body Dementia 10.07.2010
Anti-Aging Protein Turns on Beneficial Anti-Alzheimer Disease Gene 09.16.2010
AD BIOMARKERS YEARS BEFORE ONSET OF SYMPTOMS 09.16.2010
Insulin Resistance Linked to AD Plaque 15 Years Later 09.02.2010
Advances Reported In Targeting Pathology in Alzheimer Disease 08.19.2010
Advances Reported In Targeting Pathology in Alzheimer Disease 08.19.2010
New Studies Identify Depression as Risk Factor for Cognitive Decline 07.15.2010
Caution Greets Report of New Gene for Alzheimer Disease 07.01.2010
Evidence Points to Amyloid Beta as the Key to Alzheimer Disease 05.20.2010

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Alzheimer's Disease

Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called dementias that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.There are three major hallmarks in the brain that are associated with the disease processes of AD.Amyloid plaques, which are made up of fragments of a protein called beta-amyloid peptide mixed with a collection of additional proteins, remnants of neurons, and bits and pieces of other nerve cells.Neurofibrillary tangles (NFTs), found inside neurons, are abnormal collections of a protein called tau. Normal tau is required for healthy neurons. However, in AD, tau clumps together. As a result, neurons fail to function normally and eventually die.Loss of connections between neurons responsible for memory and learning. Neurons can't survive when they lose their connections to other neurons. As neurons die throughout the brain, the affected regions begin to atrophy, or shrink. By the final stage of AD, damage is widespread and brain tissue has shrunk significantly.

Treatment

Currently there are no medicines that can slow the progression of AD. However, four FDA-approved medications are used to treat AD symptoms. These drugs help individuals carry out the activities of daily living by maintaining thinking, memory, or speaking skills. They can also help with some of the behavioral and personality changes associated with AD. However, they will not stop or reverse AD and appear to help individuals for only a few months to a few years. Donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne) are prescribed to treat mild to moderate AD symptoms. Donepezil was recently approved to treat severe AD as well. The newest AD medication is memantine (Namenda), which is prescribed to treat moderate to severe AD symptoms.

Prognosis

In very few families, people develop AD in their 30s, 40s, and 50s. This is known as "early onset" AD. These individuals have a mutation in one of three different inherited genes that causes the disease to begin at an earlier age. More than 90 percent of AD develops in people older than 65. This form of AD is called "late-onset" AD, and its development and pattern of damage in the brain is similar to that of early-onset AD. The course of this disease varies from person to person, as does the rate of decline. In most people with AD, symptoms first appear after age 65.We don't yet completely understand the causes of late-onset AD, but they probably include genetic, environmental, and lifestyle factors. Although the risk of developing AD increases with age, AD and dementia symptoms are not a part of normal aging. There are also some forms of dementia that aren't related to brain diseases such as AD, but are caused by systemic abnormalities such as metabolic syndrome, in which the combination of high blood pressure, high cholesterol, and diabetes causes confusion and memory loss.

Research

The National Institute of Neurological Disorders and Stroke (NINDS) supports basic and translational research related to AD through grants to major medical institutions across the country. Current studies are investigating how the development of beta amyloid plaques damages neurons, and how abnormalities in tau proteins create the characteristic neurofibrillary tangles of AD. Other research is exploring the impact of risk factors associated with the development of AD, such as pre-existing problems with blood flow in the blood vessels of the brain. Most importantly, the NINDS supports a number of studies that are developing and testing new and novel therapies that can relieve the symptoms of AD and potentially lead to a cure.On May 15, 2012 the Obama Administration announced the release of the National Alzheimer’s Plan. U.S. Secretary of Health and Human Services Kathleen Sebelius reaffirmed our nation’s commitment to conquering Alzheimer’s disease and related dementias, with a specific goal of finding effective ways to prevent and treat the disease by 2025.

View a list of studies currently seeking patients.

View more studies on this condition.

Read additional information from Medline Plus.

Organizations

Alzheimer's Disease Education and Referral Center (ADEAR)

National Institute on Aging
P.O. Box 8250
Silver Spring, MD 20907-8250
Tel: 1-800-438-4380
Fax: 301-495-3334

National Institute of Mental Health (NIMH)

National Institutes of Health, DHHS
6001 Executive Blvd. Rm. 8184, MSC 9663
Bethesda, MD 20892-9663
Tel: 301-443-4513/866-415-8051 301-443-8431 (TTY)
Fax: 301-443-4279

Alzheimer's Association

National voluntary health organization committed to finding a cure for Alzheimer’s and helping those affected by the disease.

225 North Michigan Avenue
Floor 17
Chicago, IL 60601-7633
Tel: 312-335-8700 1-800-272-3900 (24-hour helpline) TDD: 312-335-5886
Fax: 866.699.1246

Alzheimer's Foundation of America

Works to provide optimal care and services to individuals confronting dementia and to their caregivers and families thruogh member organizations dedicated to improving quality of life.

322 Eighth Avenue
7th Floor
New York, NY 10001
Tel: 866-AFA-8484 (232-8484)
Fax: 646-638-1546

Association for Frontotemporal Degeneration (AFTD)

Nonprofit organization that promotes and funds research into finding the cause and cure for frontotemporal degeneration, also called frontotemporal dementia (FTD); provides information, education, and support to those affected by FTD and their caregivers; and sponsors professional health education programs related to FTD.

Radnor Station Building #2 Suite 320
290 King of Prussia Road
Radnor, PA 19087
Tel: 267-514-7221 866-507-7222

BrightFocus Foundation

Non-profit charitable organization dedicated to funding research and educating the public on Alzheimer's disease, glaucoma, and macular degeneration.

22512 Gateway Center Drive
Clarksburg, MD 20871
Tel: 1- 800-437-2423
Fax: 301-258-9454

Alzheimer’s Drug Discovery Foundation

Public charity whose mission is to accelerate the discovery and development of drugs to prevent, treat, and cure Alzheimer's disease, related dementias, and cognitive aging.

57 West 57th Street
Suite 904
New York, NY 10019
Tel: 212-901-8000
Fax: 212-901-8010

John Douglas French Alzheimer's Foundation

Provides seed money for novel and innovative Alzheimer's research at major California universities. Unsolicited applications and/or letters of inquiry not accepted.

11620 Wilshire Blvd.
Suite 270
Los Angeles, CA 90025
Tel: 310-445-4650
Fax: 310-479-0516

Lewy Body Dementia Association

Supports those affected by Lewy body dementias through outreach, education and research.

912 Killian Hill Road, S.W.
Lilburn, GA 30047
Tel: Telephone: 404-935-6444 LBD Caregiver Link: 800-539-9767
Fax: 480-422-5434

National Organization for Rare Disorders (NORD)

Federation of voluntary health organizations dedicated to helping people with rare "orphan" diseases and assisting the organizations that serve them. Committed to the identification, treatment, and cure of rare disorders through programs of education, advocacy, research, and service.

55 Kenosia Avenue
Danbury, CT 06810
Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)
Fax: 203-798-2291

Family Caregiver Alliance/ National Center on Caregiving

Supports and assists families and caregivers of adults with debilitating health conditions. Offers programs and consultation on caregiving issues at local, state, and national levels. Offers free publications and support online, including a national directory of publicly funded caregiver support programs.

785 Market St.
Suite 750
San Francisco, CA 94103
Tel: 415-434-3388 800-445-8106
Fax: 415-434-3508

National Respite Network and Resource Center

Information and referral service that assists and promotes the development of quality respite and crisis care programs; helps families locate respite and crisis care services in their communities; and sponsors advocacy and awareness efforts concerning respite care.

800 Eastowne Drive
Suite 105
Chapel Hill, NC 27514
Tel: 919-490-5577 x222
Fax: 919-490-4905

National Hospice and Palliative Care Organization /Natl. Hospice Foundation

Non-profit membership organization representing hospice and palliative care programs and professionals. Provides free referrals to the public for hospice listings across the United States and internationally. Distributes free packets of general information describing hospice services and the Medicare Hospice Benefit.

1731 King Street
Alexandria, VA 22314
Tel: 703-837-1500 Helpline: 800-658-8898
Fax: 703-837-1233

National Family Caregivers Association

Grassroots organization dedicated to supporting and improving the lives of America's family caregivers. Created to educate, support, empower, and advocate for the millions of Americans who care for their ill, aged, or disabled loved ones.

10400 Connecticut Avenue
Suite 500
Kensington, MD 20895-3944
Tel: 800-896-3650
Fax: 301-942-2302

Well Spouse Association

International non-profit, volunteer-based organization whose mission is to provide emotional support to, raise consciousness about, and advocate for the spouses/partners of the chronically ill and/or disabled.

63 West Main Street
Suite H
Freehold, NJ 07728
Tel: 800-838-0879 732-577-8899
Fax: 732-577-8644

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